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Hypoalbuminemia in acute ischemic stroke patients: frequency and correlates. |
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Hypoalbuminemia in acute ischemic stroke patients: frequency and correlates.
Eur J Clin Nutr. 2007 Jan 24;
Dziedzic T, Pera J, Slowik A, Gryz-Kurek EA, Szczudlik A.
1Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow, Poland.
Objective:Hypoalbuminemia
in acute stroke patients is associated with increased mortality and
morbidity. The aim of our study was to determine the frequency and
correlates of hypoalbuminemia in unselected cohort of patients with
acute cerebral infarction.Design:Prospective study.Setting:University
hospital.
Subjects:Seven hundred and five consecutive ischemic stroke
patients.Methods:Albumin and other serum protein fractions were
measured within 36 h after stroke using
electrophoresis.Results:Hypoalbuminemia defined as serum albumin level
<35 g/l was found in 45.5% of patients. Serum albumin level
correlates significantly with age (r=-0.13, P<0.01), Scandinavian
Stroke Scale score (r=0.14, P<0.01), body temperature on admission
(r=0.14, P<0.01), leukocyte count (r=-0.17, P<0.01), fasting
glucose (r=-0.16, P<0.01), total cholesterol (r=0.14, P<0.01),
alpha1-globulin (r=-0.48, P<0.01), alpha2-globulin (r=-0.49,
P<0.01), beta-globulin (r=-0.26, P<0.01) and gamma-globulin
(r=-0.35, P<0.01).Conclusions:Hypoalbuminemia is a frequent finding
in acute stroke patients and it is associated with more severe stroke
and pro-inflammatory pattern of serum protein electrophoresis.European
Journal of Clinical Nutrition advance online publication, 24 January
2007; doi:10.1038/sj.ejcn.1602643.
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